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Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic ef...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3879129/ https://ncbi.nlm.nih.gov/pubmed/24404420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.25912 |
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