Neocosmospora sp-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors

Bioassay-guided fractionation of a fungus Neocosmospora sp. (UM-031509) resulted in the isolation of three new resorcylic acid lactones, neocosmosin A (2), neocosmosin B (3) and neocosmosin C (4). Three known resorcylic acid lactones, monocillin IV (1), monocillin II (5) and radicicol (6) were also...

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Hlavní autoři: Gao, Jiangtao, Radwan, Mohamed M., León, Francisco, Dale, Olivia Reed, Husni, Afeef S., Wu, Yunshan, Lupien, Shari, Wang, Xiaoning, Manly, Susan P., Hill, Robert A., Dugan, Frank M., Cutler, Horace G., Cutler, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723356/
https://ncbi.nlm.nih.gov/pubmed/23659286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np300653d
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