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A coupled protein and probe engineering approach for selective inhibition and activity based probe labeling of the caspases
Caspases are cysteine proteases that play essential roles in apoptosis and inflammation. Unfortunately, their highly conserved active sites and overlapping substrate specificities make it difficult to use inhibitors or activity-based probes to study the function, activation, localization and regulat...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3722599/ https://ncbi.nlm.nih.gov/pubmed/23701470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja403521u |
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