TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

BACKGROUND & AIMS: Tight junction dysregulation and epithelial damage contribute to barrier loss in patients with inflammatory bowel disease (IBD). However, the mechanisms that regulate these processes and their relative contributions to disease pathogenesis are incompletely understood. We inves...

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Hauptverfasser: Su, Liping, Nalle, Sam C., Shen, Le, Turner, Emily S., Singh, Gurminder, Breskin, Lydia A., Khramtsova, Ekaterina A., Khramtsova, Galina, Tsai, Pei-Yun, Fu, Yang-Xin, Abraham, Clara, Turner, Jerrold R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722284/
https://ncbi.nlm.nih.gov/pubmed/23619146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.04.011
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