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PGC-1α, Mitochondrial Dysfunction and Huntington’s Disease

The constant high energy demand of neurons makes them rely heavily on their mitochondria. Dysfunction of mitochondrial energy metabolism leads to reduced ATP production, impaired calcium buffering, and generation of reactive oxygen species. There is strong evidence that mitochondrial dysfunction res...

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Detalhes bibliográficos
Main Authors: Johri, Ashu, Chandra, Abhishek, Beal, M. Flint
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722269/
https://ncbi.nlm.nih.gov/pubmed/23602910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.04.016
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