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Crystal Structure of the N-Acetyltransferase Domain of Human N-Acetyl-L-Glutamate Synthase in Complex with N-Acetyl-L-Glutamate Provides Insights into Its Catalytic and Regulatory Mechanisms

N-acetylglutamate synthase (NAGS) catalyzes the conversion of AcCoA and L-glutamate to CoA and N-acetyl-L-glutamate (NAG), an obligate cofactor for carbamyl phosphate synthetase I (CPSI) in the urea cycle. NAGS deficiency results in elevated levels of plasma ammonia which is neurotoxic. We report he...

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Autors principals: Zhao, Gengxiang, Jin, Zhongmin, Allewell, Norma M., Tuchman, Mendel, Shi, Dashuang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722096/
https://ncbi.nlm.nih.gov/pubmed/23894642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070369
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