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Mechanism of Allosteric Inhibition of N-Acetyl-L-glutamate Synthase by L-Arginine

N-Acetylglutamate synthase (NAGS) catalyzes the first committed step in l-arginine biosynthesis in plants and micro-organisms and is subject to feedback inhibition by l-arginine. This study compares the crystal structures of NAGS from Neisseria gonorrhoeae (ngNAGS) in the inactive T-state with l-arg...

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Библиографические подробности
Главные авторы: Min, Li, Jin, Zhongmin, Caldovic, Ljubica, Morizono, Hiroki, Allewell, Norma M., Tuchman, Mendel, Shi, Dashuang
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643497/
https://ncbi.nlm.nih.gov/pubmed/19095660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805348200
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