Methylation levels of LINE-1 in primary lesion and matched metastatic lesions of colorectal cancer

BACKGROUND: LINE-1 methylation level is a surrogate marker of global DNA methylation. LINE-1 methylation in primary colorectal cancers (CRCs) is highly variable and strongly associated with a poor prognosis. However, no study has examined LINE-1 methylation levels of metastatic CRCs in relation to p...

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Detalhes bibliográficos
Main Authors: Murata, A, Baba, Y, Watanabe, M, Shigaki, H, Miyake, K, Ishimoto, T, Iwatsuki, M, Iwagami, S, Sakamoto, Y, Miyamoto, Y, Yoshida, N, Nosho, K, Baba, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721399/
https://ncbi.nlm.nih.gov/pubmed/23764749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.289
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