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An Obligatory Role for Lung Infiltrating B Cells in the Immunopathogenesis of Obliterative Airway Disease Induced by Antibodies to MHC class I Molecules

Using a murine model, we demonstrated that endobronchial administration of antibodies (Abs) to MHC class I results in cellular infiltration, epithelial metaplasia, fibrosis and obstruction of the small airways (Obliterative Airway Disease (OAD)) mediated predominantly by Th17 responses to self-antig...

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Bibliografiske detaljer
Main Authors: Fukami, N., Ramachandran, S., Takenaka, M., Weber, J., Subramanian, V., Mohanakumar, T.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721353/
https://ncbi.nlm.nih.gov/pubmed/22233464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2011.03917.x
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