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An Obligatory Role for Lung Infiltrating B Cells in the Immunopathogenesis of Obliterative Airway Disease Induced by Antibodies to MHC class I Molecules
Using a murine model, we demonstrated that endobronchial administration of antibodies (Abs) to MHC class I results in cellular infiltration, epithelial metaplasia, fibrosis and obstruction of the small airways (Obliterative Airway Disease (OAD)) mediated predominantly by Th17 responses to self-antig...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3721353/ https://ncbi.nlm.nih.gov/pubmed/22233464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2011.03917.x |
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