Ns1 Is a Key Protein in the Vaccine Composition to Protect Ifnar(−/−) Mice against Infection with Multiple Serotypes of African Horse Sickness Virus

African horse sickness virus (AHSV) belongs to the genus Orbivirus. We have now engineered naked DNAs and recombinant modified vaccinia virus Ankara (rMVA) expressing VP2 and NS1 proteins from AHSV-4. IFNAR((−/−)) mice inoculated with DNA/rMVA-VP2,-NS1 from AHSV-4 in an heterologous prime-boost vacc...

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Detalhes bibliográficos
Main Authors: de la Poza, Francisco, Calvo-Pinilla, Eva, López-Gil, Elena, Marín-López, Alejandro, Mateos, Francisco, Castillo-Olivares, Javier, Lorenzo, Gema, Ortego, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720900/
https://ncbi.nlm.nih.gov/pubmed/23894615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070197
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