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Evolution of a designed retro-aldolase leads to complete active site remodeling
Evolutionary advances are often fueled by unanticipated innovation. Directed evolution of a computationally designed enzyme suggests that dramatic molecular changes can also drive the optimization of primitive protein active sites. The specific activity of an artificial retro-aldolase was boosted &g...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3720730/ https://ncbi.nlm.nih.gov/pubmed/23748672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1276 |
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