Hemoglobin Indianapolis (beta 112[G14] arginine). An unstable beta-chain variant producing the phenotype of severe beta-thalassemia.

Hemoglobin (Hb) Indianapolis is an extremely labile beta-chain variant, present in such small amounts that it was undetectable by usual techniques. Clinically, it produces the phenotype of severe beta-thalassemia. Biosynthetic studies showed a beta:alpha ratio of 0.5 in reticulocytes and about 1.0 i...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Adams, J G, Boxer, L A, Baehner, R L, Forget, B G, Tsistrakis, G A, Steinberg, M H
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 1979
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372034/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/447835/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109393
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