Posttranscriptional defects in beta-globin messenger RNA metabolism in beta-thalassemia: abnormal accumulation of beta-messenger RNA precursor sequences.

The production of beta-globin messenger RNA (mRNA) in beta-thalassemic erythroblasts was studied during pulse-chase incubations with [3H]uridine. Globin [3H]mRNA was quantitated by molecular hybridization to recombinant DNA probes complementary to globin mRNA and mRNA precursor sequences. Each of si...

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Библиографические подробности
Главные авторы: Benz, E J, Scarpa, A L, Tonkonow, B L, Pearson, H A, Ritchey, A K
Формат: Artigo
Язык:Inglês
Опубликовано: 1981
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC370957/
https://ncbi.nlm.nih.gov/pubmed/7320200
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