Posttranscriptional defects in beta-globin messenger RNA metabolism in beta-thalassemia: abnormal accumulation of beta-messenger RNA precursor sequences.

The production of beta-globin messenger RNA (mRNA) in beta-thalassemic erythroblasts was studied during pulse-chase incubations with [3H]uridine. Globin [3H]mRNA was quantitated by molecular hybridization to recombinant DNA probes complementary to globin mRNA and mRNA precursor sequences. Each of si...

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Pubblicato in:	J Clin Invest
Autori principali:	Benz, E J, Scarpa, A L, Tonkonow, B L, Pearson, H A, Ritchey, A K
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1981
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370957/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7320200/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110407
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