Combinatorial targeting of 2 different steps in adenoviral DNA replication by herpes simplex virus thymidine kinase and artificial microRNA expression for the inhibition of virus multiplication in the presence of ganciclovir

BACKGROUND: Human adenoviruses are a frequent threat to immunocompromised patients, and disseminated disease is associated with severe morbidity and mortality. Current drugs are not capable of preventing all fatalities, thus indicating the need for alternative treatment strategies. Adenoviruses can...

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Bibliographic Details
Main Authors: Ibrišimović, Mirza, Lion, Thomas, Klein, Reinhard
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720212/
https://ncbi.nlm.nih.gov/pubmed/23822768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-13-54
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