Immunoglobulin G independent activation of the classical complement pathway by monosodium urate crystals.
10 mg of monosodium urate crystals reduced the CH50 of 1 ml of human serum by 57% after 30 min at 37 degrees C. C1, C4, and C3 depletion of 52, 68, and 46% were typical of classical pathway activation. C1 binding and activation occurred when urate crystals were incubated with isolated precursor C1,...
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| Publicado no: | J Clin Invest |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
1979
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372012/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/438335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109360 |
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