Induction of Cell Death, DNA Strand Breaks, and Cell Cycle Arrest in DU145 Human Prostate Carcinoma Cell Line by Benzo[a]pyrene and Benzo[a]pyrene-7,8-diol-9,10-epoxide

Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma cell line DU145, were examined. Cell viability, DN...

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Bibliographic Details
Main Authors: Nwagbara, Onyinye, Darling-Reed, Selina F., Tucker, Alicia, Harris, Cynthia, Abazinge, Michael, Thomas, Ronald D., Gragg, Richard D.
Format: Artigo
Language:Inglês
Published: Molecular Diversity Preservation International (MDPI) 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719953/
https://ncbi.nlm.nih.gov/pubmed/17431309
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