Cell Type-Specific Dependency on the PI3K/Akt Signaling Pathway for the Endogenous Epo and VEGF Induction by Baicalein in Neurons versus Astrocytes

The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-α (HIF1α) through inhibition of prolyl hydrolase 2 (PHD2) and activati...

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Bibliografske podrobnosti
Main Authors: Sun, Yu-Yo, Lin, Shang-Hsuan, Lin, Hung-Cheng, Hung, Chia-Chi, Wang, Chen-Yu, Lin, Yen-Chu, Hung, Kuo-Sheng, Lien, Cheng-Chang, Kuan, Chia-Yi, Lee, Yi-Hsuan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719842/
https://ncbi.nlm.nih.gov/pubmed/23904909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069019
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