N-Linked Glycosylation of the Hemagglutinin Protein Influences Virulence and Antigenicity of the 1918 Pandemic and Seasonal H1N1 Influenza A Viruses

The hemagglutinin (HA) protein is a major virulence determinant for the 1918 pandemic influenza virus; however, it encodes no known virulence-associated determinants. In comparison to seasonal influenza viruses of lesser virulence, the 1918 H1N1 virus has fewer glycosylation sequons on the HA globul...

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Detalhes bibliográficos
Main Authors: Sun, Xiangjie, Jayaraman, Akila, Maniprasad, Pavithra, Raman, Rahul, Houser, Katherine V., Pappas, Claudia, Zeng, Hui, Sasisekharan, Ram, Katz, Jacqueline M., Tumpey, Terrence M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719814/
https://ncbi.nlm.nih.gov/pubmed/23740978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00593-13
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