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The Kinase Activity of Ataxia-Telangiectasia Mutated Interferes with Adenovirus E4 Mutant DNA Replication

Adenovirus (Ad) mutants that lack early region 4 (E4) are unable to produce the early regulatory proteins that normally inactivate the Mre11/Rad50/Nbs1 (MRN) sensor complex, which is a critical component for the ability of cells to respond to DNA damage. E4 mutant infection therefore activates a DNA...

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Detalhes bibliográficos
Main Authors: Gautam, Dipendra, Bridge, Eileen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719797/
https://ncbi.nlm.nih.gov/pubmed/23740981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00376-13
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