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HIV-1 Gag Cytotoxic T Lymphocyte Epitopes Vary in Presentation Kinetics Relative to HLA Class I Downregulation

Although CD8(+) cytotoxic T lymphocytes (CTLs) are protective in HIV-1 infection, the factors determining their antiviral efficiency are poorly defined. It is proposed that Gag targeting is superior because of very early Gag epitope presentation, allowing early killing of infected cells before Nef-m...

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Main Authors: Balamurugan, Arumugam, Ali, Ayub, Boucau, Julie, Le Gall, Sylvie, Ng, Hwee L., Yang, Otto O.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719789/
https://ncbi.nlm.nih.gov/pubmed/23740989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01040-13
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