Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing

Krüppel-like factors 3 and 8 (KLF3 and KLF8) are highly related transcriptional regulators that bind to similar sequences of DNA. We have previously shown that in erythroid cells there is a regulatory hierarchy within the KLF family, whereby KLF1 drives the expression of both the Klf3 and Klf8 genes...

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Main Authors: Funnell, Alister P. W., Mak, Ka Sin, Twine, Natalie A., Pelka, Gregory J., Norton, Laura J., Radziewic, Tania, Power, Melinda, Wilkins, Marc R., Bell-Anderson, Kim S., Fraser, Stuart T., Perkins, Andrew C., Tam, Patrick P., Pearson, Richard C. M., Crossley, Merlin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719677/
https://ncbi.nlm.nih.gov/pubmed/23716600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00074-13
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