Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Genetic alterations in kinases have been linked to multiple human pathologies. To explore the landscape of kinase genetic variation in gastric cancer (GC), we used targeted, paired-end deep sequencing to analyze 532 protein and phosphoinositide kinases in 14 GC cell lines. We identified 10,604 singl...

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Autores principales: Zang, Zhi Jiang, Ong, Choon Kiat, Cutcutache, Ioana, Yu, Willie, Zhang, Shen Li, Huang, Dachuan, Ler, Lian Dee, Dykema, Karl, Gan, Anna, Tao, Jiong, Lim, Siyu, Liu, Yujing, Futreal, P. Andrew, Grabsch, Heike, Furge, Kyle A., Goh, Liang Kee, Rozen, Steve, Teh, Bin Tean, Tan, Patrick
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719377/
https://ncbi.nlm.nih.gov/pubmed/21097718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1749
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