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Ligand promiscuity through the eyes of the aminoglycoside N3 acetyltransferase IIa
Aminoglycoside-modifying enzymes (AGMEs) are expressed in many pathogenic bacteria and cause resistance to aminoglycoside (AG) antibiotics. Remarkably, the substrate promiscuity of AGMEs is quite variable. The molecular basis for such ligand promiscuity is largely unknown as there is not an obvious...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Publishing Ltd
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3719086/ https://ncbi.nlm.nih.gov/pubmed/23640799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2273 |
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