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Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function

Despite recent advances in biomaterial science, there is yet no culture system that supports long-term culture expansion of human adult hepatocytes, while preserving continued function. Previous studies suggested that acellular liver extracellular matrix (ECM), employed as a substrate, improved prol...

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Autori principali: Skardal, Aleksander, Smith, Leona, Bharadwaj, Shantaram, Atala, Anthony, Soker, Shay, Zhang, Yuanyuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719050/
https://ncbi.nlm.nih.gov/pubmed/22475531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.03.034
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