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Transcriptional Regulation of Bim by FOXO3a and Akt Mediates Scleroderma Serum-Induced Apoptosis in Endothelial Progenitor Cells
BACKGROUND: Endothelial progenitor cells (EPCs) contribute to vascular regeneration/repair, and may thus protect against scleroderma vasculopathy. We aimed to determine (i) whether circulating EPCs were reduced in scleroderma; and (ii) whether scleroderma sera could induce EPC apoptosis and, if so,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3719010/ https://ncbi.nlm.nih.gov/pubmed/18981303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.787200 |
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