Transcriptional Regulation of Bim by FOXO3a and Akt Mediates Scleroderma Serum-Induced Apoptosis in Endothelial Progenitor Cells

BACKGROUND: Endothelial progenitor cells (EPCs) contribute to vascular regeneration/repair, and may thus protect against scleroderma vasculopathy. We aimed to determine (i) whether circulating EPCs were reduced in scleroderma; and (ii) whether scleroderma sera could induce EPC apoptosis and, if so,...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhu, Shoukang, Evans, Sarah, Yan, Bin, Povsic, Thomas J., Tapson, Victor, Goldschmidt-Clermont, Pascal J., Dong, Chunming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719010/
https://ncbi.nlm.nih.gov/pubmed/18981303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.787200
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