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Cell signaling abnormalities may drive neurodegeneration in Familial Alzheimer disease
Presenilins (PSs) are catalytic components of the γ-secretase complex that produces Aβ peptides. Substrates of γ-secretase are membrane-bound protein fragments deriving from the cleavage of extracellular sequence of cell surface proteins. APP-derived γ-secretase substrates are cleaved at gamma (γ) s...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3718870/ https://ncbi.nlm.nih.gov/pubmed/23436150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-013-1003-6 |
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