A Phase I Study of Vincristine, Irinotecan, Temozolomide and Bevacizumab (Vitb) in Pediatric Patients with Relapsed Solid Tumors

BACKGROUND: To determine the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of irinotecan administered in combination with vincristine, temozolomide and bevacizumab in children with refractory solid tumors. METHODS: The study design included two dose levels (DL) of irinotecan given in...

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Hauptverfasser: Venkatramani, Rajkumar, Malogolowkin, Marcio, Davidson, Tom B., May, William, Sposto, Richard, Mascarenhas, Leo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718768/
https://ncbi.nlm.nih.gov/pubmed/23894304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068416
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