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Biological function of Presenilin and its role in AD pathogenesis
Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components – presenilins and their biological fu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3718700/ https://ncbi.nlm.nih.gov/pubmed/23866842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2047-9158-2-15 |
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