Aberrant HDAC2-Mediated Histone Modifications and Synaptic Plasticity in the Amygdala Predisposes to Anxiety and Alcoholism

BACKGROUND: Epigenetic mechanisms have been implicated in psychiatric disorders, including alcohol dependence. However, the epigenetic basis and role of specific histone deacetylase (HDAC) isoforms in the genetic predisposition to anxiety and alcoholism is unknown. METHODS: We measured amygdaloid HD...

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Bibliografiske detaljer
Main Authors: Moonat, Sachin, Sakharkar, Amul J., Zhang, Huaibo, Tang, Lei, Pandey, Subhash C.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718567/
https://ncbi.nlm.nih.gov/pubmed/23485013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.01.012
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