The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets.

NH4+ caused a dose-related, rapid, and reversible inhibition of glucose-stimulated insulin release by isolated rat islets. It also inhibited glyceraldehyde-, Ba2+-, and sulfonylurea-stimulated insulun secretion. NH4+ failed to affect glucose utilization and oxidation, glucose-stimulated proinsulin b...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Sener, A, Hutton, J C, Kawazu, S, Boschero, A C, Somers, G, Devis, G, Herchuelz, A, Malaisse, W J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1978
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371839/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/29912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109199
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