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Molecular logistics using cytocleavable polyrotaxanes for the reactivation of enzymes delivered in living cells

The intracellular delivery of enzymes is an essential methodology to extend their therapeutic application. Herein, we have developed dissociable supermolecule-enzyme polyelectrolyte complexes based on reduction-cleavable cationic polyrotaxanes (PRXs) for the reactivation of delivered enzymes. These...

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Bibliografski detalji
Glavni autori: Tamura, Atsushi, Ikeda, Go, Seo, Ji-Hun, Tsuchiya, Koji, Yajima, Hirofumi, Sasaki, Yoshihiro, Akiyoshi, Kazunari, Yui, Nobuhiko
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718191/
https://ncbi.nlm.nih.gov/pubmed/23872688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02252
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