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Impaired endolysosomal function disrupts Notch signaling in optic nerve astrocytes

Astrocytes migrate from the optic nerve into the inner retina, forming a template upon which retinal vessels develop. In the Nuc1 rat, mutation in the gene encoding βA3/A1-crystallin disrupts both Notch signaling in astrocytes and formation of the astrocyte template. Here we show that loss of βA3/A1...

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Dettagli Bibliografici
Autori principali: Valapala, Mallika, Hose, Stacey, Gongora, Celine, Dong, Lijin, Wawrousek, Eric F., Zigler, J. Samuel, Sinha, Debasish
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718029/
https://ncbi.nlm.nih.gov/pubmed/23535650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2624
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