Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats

Impaired counterregulation during hypoglycemia in type 1 diabetes (T1D) is partly attributable to inadequate glucagon secretion. Intra-islet somatostatin (SST) suppression of hypoglycemia-stimulated α-cell glucagon release plays an important role. We hypothesized that hypoglycemia can be prevented i...

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Autors principals: Karimian, Negar, Qin, Tairan, Liang, Tao, Osundiji, Mayowa, Huang, Yachi, Teich, Trevor, Riddell, Michael C., Cattral, Mark S., Coy, David H., Vranic, Mladen, Gaisano, Herbert Y.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717832/
https://ncbi.nlm.nih.gov/pubmed/23630299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0164
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