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Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation
Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane repair, macrophages respond to pore-forming toxins through activation of the NLRP3 inflammasome, leading to IL-1β secretion and pyroptosis. The st...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
MDPI
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3717772/ https://ncbi.nlm.nih.gov/pubmed/23744055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins5061105 |
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