Synthetic lipid membrane channels formed by designed DNA nanostructures

We created nanometer-scale transmembrane channels in lipid bilayers using self-assembled DNA-based nanostructures. Scaffolded DNA origami was used to create a stem that penetrates and spans a lipid membrane, and a barrel-shaped cap that adheres to the membrane in part via 26 cholesterol moieties. In...

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Main Authors: Langecker, Martin, Arnaut, Vera, Martin, Thomas G., List, Jonathan, Renner, Stephan, Mayer, Michael, Dietz, Hendrik, Simmel, Friedrich C.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716461/
https://ncbi.nlm.nih.gov/pubmed/23161995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1225624
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