Mitochondria Oxidative Stress, Connexin43 Remodeling, and Sudden Arrhythmic Death

BACKGROUND: Previously, we showed a mouse model (ACE8/8) of cardiac renin-angiotensin system (RAS) activation has a high rate of spontaneous ventricular tachycardia (VT) and sudden cardiac death (SCD) secondary to a reduction in connexin43 (Cx43) level. Angiotensin-II activation increases reactive o...

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Main Authors: Sovari, Ali A., Rutledge, Cody A., Jeong, Euy-Myoung, Dolmatova, Elena, Arasu, Divya, Liu, Hong, Vahdani, Nooshin, Gu, Lianzhi, Zandieh, Shadi, Xiao, Lei, Bonini, Marcelo G., Duffy, Heather S., Dudley, Samuel C.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716298/
https://ncbi.nlm.nih.gov/pubmed/23559673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.112.976787
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