Synaptic PRG-1 Modulates Excitatory Transmission via Lipid Phosphate-Mediated Signaling

Plasticity related gene-1 (PRG-1) is a brain-specific membrane protein related to lipid phosphate phosphatases, which acts in the hippocampus specifically at the excitatory synapse terminating on glutamatergic neurons. Deletion of prg-1 in mice leads to epileptic seizures and augmentation of EPSCs,...

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Autors principals: Trimbuch, Thorsten, Beed, Prateep, Vogt, Johannes, Schuchmann, Sebastian, Maier, Nikolaus, Kintscher, Michael, Breustedt, Jörg, Schuelke, Markus, Streu, Nora, Kieselmann, Olga, Brunk, Irene, Laube, Gregor, Strauss, Ulf, Battefeld, Arne, Wende, Hagen, Birchmeier, Carmen, Wiese, Stefan, Sendtner, Michael, Kawabe, Hiroshi, Kishimoto-Suga, Mika, Brose, Nils, Baumgart, Jan, Geist, Beate, Aoki, Junken, Savaskan, Nic E., Bräuer, Anja U., Chun, Jerold, Ninnemann, Olaf, Schmitz, Dietmar, Nitsch, Robert
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716297/
https://ncbi.nlm.nih.gov/pubmed/19766573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.06.050
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