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Total Synthesis of Aplyronine C

[Image: see text] A highly stereocontrolled total synthesis of the cytotoxic marine macrolide aplyronine C is described. The route exploits aldol methodology to install the requisite stereochemistry and features a crucial boron-mediated aldol coupling of an N-vinylformamide-bearing methyl ketone wit...

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Detalhes bibliográficos
Main Authors: Paterson, Ian, Fink, Sarah J., Lee, Lydia Y. W., Atkinson, Stephen J., Blakey, Simon B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715889/
https://ncbi.nlm.nih.gov/pubmed/23730909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol401327r
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