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PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins
A major limitation of biopharmaceutical proteins is their fast clearance from circulation via kidney filtration, which strongly hampers efficacy both in animal studies and in human therapy. We have developed conformationally disordered polypeptide chains with expanded hydrodynamic volume comprising...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3715784/ https://ncbi.nlm.nih.gov/pubmed/23754528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzt023 |
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