Th2 cytokines from malignant cells suppress Th1 responses and enforce a global Th2 bias in leukemic cutaneous T cell lymphoma

PURPOSE: In leukemic CTCL (L-CTCL) malignant T cells accumulate in the blood and give rise to widespread skin inflammation. Patients have intense pruritus, increased IgE, decreased Th1 responses and most die from infection. Depleting malignant T cells while preserving normal immunity is a clinical c...

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Detalhes bibliográficos
Main Authors: Guenova, Emmanuella, Watanabe, Rei, Teague, Jessica E., Desimone, Jennifer A., Jiang, Ying, Dowlatshahi, Mitra, Gehad, Ahmed, Schlapbach, Christoph, Schaekel, Knut, Rook, Alain H., Tawa, Marianne, Fisher, David C., Kupper, Thomas S., Clark, Rachael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715586/
https://ncbi.nlm.nih.gov/pubmed/23785046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3488
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