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Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1

SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. This restriction is alleviated by expression of the lentiviral accessory proteins Vpx and Vpr (Vpx/Vpr), which target SAMHD1 for proteasome...

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Bibliografiske detaljer
Main Authors: Fregoso, Oliver I., Ahn, Jinwoo, Wang, Chuanping, Mehrens, Jennifer, Skowronski, Jacek, Emerman, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715410/
https://ncbi.nlm.nih.gov/pubmed/23874202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003496
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