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Improving Pharmacokinetic-Pharmacodynamic Modeling to Investigate Anti-Infective Chemotherapy with Application to the Current Generation of Antimalarial Drugs

Mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) modelling is the standard computational technique for simulating drug treatment of infectious diseases with the potential to enhance our understanding of drug treatment outcomes, drug deployment strategies, and dosing regimens. Standard methodo...

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Detalhes bibliográficos
Main Authors: Kay, Katherine, Hastings, Ian M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715401/
https://ncbi.nlm.nih.gov/pubmed/23874190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003151
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