Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.

To assess the mechanisms of the insulin resistance in human obesity, we have determined, using a modification of the euglycemic glucose clamp technique, the shape of the in vivo insulin-glucose disposal dose-response curves in 7 control and 13 obese human subjects. Each subject had at least three eu...

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Pubblicato in:	J Clin Invest
Autori principali:	Kolterman, O G, Insel, J, Saekow, M, Olefsky, J M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1980
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371464/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6997333/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109790
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