RIG-I activation inhibits HIV replication in macrophages

The RIG-I signaling pathway is critical in the activation of the type I IFN-dependent antiviral innate-immune response. We thus examined whether RIG-I activation can inhibit HIV replication in macrophages. We showed that the stimulation of monocyte-derived macrophages with 5′ppp-dsRNA, a synthetic l...

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Bibliografiske detaljer
Main Authors: Wang, Yizhong, Wang, Xu, Li, Jieliang, Zhou, Yu, Ho, Wenzhe
Format: Artigo
Sprog:Inglês
Udgivet: Society for Leukocyte Biology 2013
Fag:
Receptors, Signal Transduction, & Genes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714567/
https://ncbi.nlm.nih.gov/pubmed/23744645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0313158
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