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The N276 Glycosylation Site Is Required for HIV-1 Neutralization by the CD4 Binding Site Specific HJ16 Monoclonal Antibody

Immunogen design for HIV-1 vaccines could be based on epitope identification of naturally occurring neutralizing antibodies in infected patients. A tier 2 neutralizing monoclonal antibody (mAb), HJ16 recognizes a new epitope in the CD4 binding site (CD4bs) region that only partially overlaps with th...

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Detalhes bibliográficos
Main Authors: Balla-Jhagjhoorsingh, Sunita S., Corti, Davide, Heyndrickx, Leo, Willems, Elisabeth, Vereecken, Katleen, Davis, David, Vanham, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714269/
https://ncbi.nlm.nih.gov/pubmed/23874792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068863
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