Increased Tumorigenicity and Sensitivity to Ionizing Radiation upon Loss of Chromosomal Protein HMGN1

We report that loss of HMGN1, a nucleosome-binding protein that alters the compaction of the chromatin fiber, increases the cellular sensitivity to ionizing radiation and the tumor burden of mice. The mortality and tumor burden of ionizing radiation–treated Hmgn1(−/−) mice is higher than that of the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Birger, Yehudit, Catez, Frédéric, Furusawa, Takashi, Lim, Jae-Hwan, Prymakowska-Bosak, Marta, West, Katherine L., Postnikov, Yuri V., Haines, Diana C., Bustin, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2005
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714215/
https://ncbi.nlm.nih.gov/pubmed/16061652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-05-0310
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