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Kisspeptin Activation of TRPC4 Channels in Female GnRH Neurons Requires PIP(2) Depletion and cSrc Kinase Activation

Kisspeptin signaling via its Gαq-coupled receptor GPR54 plays a crucial role in modulating GnRH neuronal excitability, which controls pituitary gonadotropins secretion and ultimately reproduction. Kisspeptin potently depolarizes GnRH neurons primarily through the activation of canonical transient re...

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Bibliografske podrobnosti
Main Authors: Zhang, Chunguang, Bosch, Martha A., Rønnekleiv, Oline K., Kelly, Martin J.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713215/
https://ncbi.nlm.nih.gov/pubmed/23744639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1180
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