Vitamin C restores healthy aging in a mouse model for Werner syndrome

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many phenotypic features of WS, including a prooxidant status and a shorter mean life span compared to wild-type animals. Here, we show th...

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Main Authors: Massip, Laurent, Garand, Chantal, Paquet, Eric R., Cogger, Victoria C., O’Reilly, Jennifer N., Tworek, Leslee, Hatherell, Avril, Taylor, Carla G., Thorin, Eric, Zahradka, Peter, Le Couteur, David G., Lebel, Michel
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712979/
https://ncbi.nlm.nih.gov/pubmed/19741171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-137133
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